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Information × Registration Number 0220U102626, 0118U003727 , R & D reports Title Identify ways to reduce disability in patients with localized kidney cancer based on the development and optimization of innovative diagnostic methods, neoadjuvant targeted therapy and surgical treatment. popup.stage_title Head Stakhovskyi Eduard O, Registration Date 13-04-2020 Organization National Cancer Institute popup.description2 It was found that carrying out neoadjuvant TT in patients with localized NKR allowed to statistically significantly increase the median volume of the functioning renal parenchyma by 21% (p <0.001), reducing the average tumor size by 11.4 mm (p <0.001), which allowed to perform NKR restaging in 37.3% of cases (p = 0.0019) and played a key role in the choice of surgical treatment in favor of renal resection. It was determined that conducting neoadjuvant TT in patients with localized NKR resulted in statistically significant tumor regression by an average of (20.4 ± 14.4) mm (17.1 - 23.8)%, with the size of the primary tumor (61, 3 ± 19.5 mm (56.5 - 65.7) mm, which provided the possibility of organ-saving operative treatment in 90.7% of cases compared with 45.5% among patients without TT (x2 = 35.5; p <0.001). It was found that neoadjuvant TT does not affect the level of both total glomerular filtration (p = 0.7) and renal function on the lesion side (p = 0.84), and does not increase the number of perioperative complications (p = 0.83), however, statistically significantly increases the volume of blood flow during kidney resection. A new system for predicting the level of tumor regression due to neo-adjuvant TT has been developed, which makes it possible to determine with 95% probability the effectiveness of reducing its size and to determine the feasibility of such treatment. It is shown that the low level of NKR regression from the 4th century. histopathological gradation of Furman nuclei (3.8 ± 2.6) mm (1.2 - 6.4)% indicates low efficiency of TT in the treatment of this category of patients (ANOVA: η2 = 0.65; power = 0.56; p <0.05), and can be used as a prognostic marker of the response. Renal resection has been shown to have a statistically significant quality of life (SF-36) benefit for patients over nephrectomy, mainly due to better psychological assessment of their health (Mann-Whitney U-test; p <0.01). Product Description popup.authors Vitruk Iurii V Vojlenko Oleg A Vukalovich Peter S Havryliuk Oksana M Kononenko Oleksiy A Pikulʹ Maksym V Pilin Yevheniy V Semko Sofiya L Stakhovsky Alexander E Tuganova Tamara M popup.nrat_date 2020-07-03 Close