Registration Number
0220U103801,
0117U006416
, R & D reports
Title
Development of nanosystems for targeted drugs delivery.
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Head
Kytova Dina Ye., Кандидат хімічних наук
Registration Date
20-11-2020
Organization
Ukrainian State University of Chemical Technology
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Object of the study - physicochemical and biological properties of nanosystems loaded with complex compounds Re(III) and Re(I). The aim of the work is to investigate the intercalation of rhenium compounds (I,III) in zirconium phosphate layers for targeted delivery of the substance, to investigate the fluorescent properties of rhenium(I) compounds in an rigid environment of zirconium hydrogen phosphate; to obtain nanoparticles based on complex compounds of rhenium(III) with teranostic properties; to summarize the results of research concerning obtained targeted nanosystems loaded with rhenium compounds (I,III) and formulate the concept of the feasibility of using targeted nanosystems loaded with Rhenium compounds in medicine and diagnostics. Research Methods - experimental studies using elemental analysis, electron and infrared (IR) -atomic absorption spectroscopy, X-ray powder diffraction, fluorescence microscopy, analysis of erythrocyte permeability. The features of intercalation of rhenium(I) compounds into zirconium hydrogen phosphate layers for targeted delivery of the substance have been determined. The luminescent properties of the obtained nanosystems loaded with rhenium(I) compounds for the implementation of a diagnostic approach to the treatment of cancer have been studied. Nanoparticles based on rhenium(III) complex compounds with teranostic properties, which combine diagnostic and therapeutic possibilities for treatment, were obtained and their effectiveness was investigated by experiments with human and mouse erythrocytes. The concept of expediency of using nanosystems of targeted action loaded with Rhenium compounds in medicine and diagnostics is formulated. Field of use: C 20.59 - Manufacture of other chemical products nec; C 21.20 - Manufacture of pharmaceutical preparations and materials; P 85.42 - Higher education; Q 86.90 - Other health care activities.
Product Description
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Velychko Olena V.
Kytova Dina Ye.
Ovcharenko Alina O.
Panteleieva Olha S.
Polokhina Kateryna S.
Slipkan Anastasiia V.
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2020-11-20
