Registration Number
0220U103890,
0118U007346
, R & D reports
Title
Functional characteristics of the spinal cord neurons and their changes under various pathologies and injuries.
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Head
Voitenko Nana V., Доктор біологічних наук
Registration Date
27-11-2020
Organization
Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine
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The spinal gray matter region around the central canal, lamina X, is critically involved in somatosensory processing and visceral nociception. Although several classes of primary afferent fibers terminate or decussate in this area, little is known about organization and functional significance of the afferent supply of lamina X neurons. Using the hemisected ex vivo spinal cord preparation, we show that virtually all lamina X neurons receive primary afferent inputs, which are predominantly mediated by the high-threshold Aδ- fibers and C-fibers. In two-thirds of the neurons tested, the inputs were monosynaptic, implying a direct targeting of the population of lamina X neurons by the primary nociceptors. In this respect, the spinal gray matter region around the central canal is similar to the superficial dorsal horn, the major spinal nociceptive processing area. We conclude that lamina X neurons integrate direct and indirect inputs from several types of thin primary afferent fibers and play an important role in nociception.
Product Description
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Agashkov Kyrilo S.
Andrianov Yaroslav Ye.
Bagatska Olena V.
Duzhyi Dmytro Ye.
Zabenko Elizaveta Yu.
Kolyada Yuriy M.
Kopach Olga V.
Kostyuk Olga I.
Kosyak Victoria V.
Krasnyakova Margarita Ye.
Mitruzaeva Valeria A.
Medvediev Volodymyr V.
Pivneva Tatyana A.
Shevchuk Diana P
Yatsenko Vasyl P.
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2020-11-27
