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Information × Registration Number 0220U104267, (0120U104095) , R & D reports Title Study of coronavirus SARS-CoV-2 protein immunogenic properties as a basis for COVID19 vaccine development. popup.stage_title Створення генетичних конструкцій, що містять гени протеїнів коронавірусу SARS-CoV-2 та їх злитих кон’югатів Head Kolybo Denys V., Доктор біологічних наук Registration Date 15-12-2020 Organization Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine popup.description1 The aim of the project is to study the immunogenic properties of recombinant SARS-CoV-2 coronavirus proteins and their conjugates with recombinant highly immunogenic carriers capable of active transport of proteins into cells using different adjuvants for immunization, as well as to develop the optimal composition of COVID19 vaccine and to conduct preclinical studies of vaccine prototype. popup.description2 Genetic constructs based on plasmid vectors containing genes of SARS-CoV-2 coronavirus proteins: nucleocapsid protein, spike protein (S) or its receptor-binding domain (RBD), their fused conjugates with carriers: diphtheria toxoid CRM197 or B-subunit of diphtheria toxin (SbB), as well as with green fluorescent protein (eGFP). In the future, the use of these constructs to produce producers of recombinant coronavirus SARS-CoV-2 proteins and their conjugates will allow to obtain safely, cheaply and in unlimited quantities antigenic substances for production of COVID19 vaccine. Product Description popup.authors Horbаtiuk Oksаnа B. Guzyk Mykhailo M. Komisarenko Serhii V. Korchynskiy Oleksandr H. Krynina Olha I. Romaniuk Svitlana I. Siromolot Andrii A. popup.nrat_date 2020-12-15 Close

Information × Registration Number 0220U104267, (0120U104095) , R & D reports Title Study of coronavirus SARS-CoV-2 protein immunogenic properties as a basis for COVID19 vaccine development. popup.stage_title Створення генетичних конструкцій, що містять гени протеїнів коронавірусу SARS-CoV-2 та їх злитих кон’югатів Head Kolybo Denys V., Доктор біологічних наук Registration Date 15-12-2020 Organization Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine popup.description1 The aim of the project is to study the immunogenic properties of recombinant SARS-CoV-2 coronavirus proteins and their conjugates with recombinant highly immunogenic carriers capable of active transport of proteins into cells using different adjuvants for immunization, as well as to develop the optimal composition of COVID19 vaccine and to conduct preclinical studies of vaccine prototype. popup.description2 Genetic constructs based on plasmid vectors containing genes of SARS-CoV-2 coronavirus proteins: nucleocapsid protein, spike protein (S) or its receptor-binding domain (RBD), their fused conjugates with carriers: diphtheria toxoid CRM197 or B-subunit of diphtheria toxin (SbB), as well as with green fluorescent protein (eGFP). In the future, the use of these constructs to produce producers of recombinant coronavirus SARS-CoV-2 proteins and their conjugates will allow to obtain safely, cheaply and in unlimited quantities antigenic substances for production of COVID19 vaccine. Product Description popup.authors Horbаtiuk Oksаnа B. Guzyk Mykhailo M. Komisarenko Serhii V. Korchynskiy Oleksandr H. Krynina Olha I. Romaniuk Svitlana I. Siromolot Andrii A. popup.nrat_date 2020-12-15 Close