Registration Number
0220U104267,
(0120U104095)
, R & D reports
Title
Study of coronavirus SARS-CoV-2 protein immunogenic properties as a basis for COVID19 vaccine development.
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Створення генетичних конструкцій, що містять гени протеїнів коронавірусу SARS-CoV-2 та їх злитих кон’югатів
Head
Kolybo Denys V., Доктор біологічних наук
Registration Date
15-12-2020
Organization
Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine
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The aim of the project is to study the immunogenic properties of recombinant SARS-CoV-2 coronavirus proteins and their conjugates with recombinant highly immunogenic carriers capable of active transport of proteins into cells using different adjuvants for immunization, as well as to develop the optimal composition of COVID19 vaccine and to conduct preclinical studies of vaccine prototype.
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Genetic constructs based on plasmid vectors containing genes of SARS-CoV-2 coronavirus proteins: nucleocapsid protein, spike protein (S) or its receptor-binding domain (RBD), their fused conjugates with carriers: diphtheria toxoid CRM197 or B-subunit of diphtheria toxin (SbB), as well as with green fluorescent protein (eGFP). In the future, the use of these constructs to produce producers of recombinant coronavirus SARS-CoV-2 proteins and their conjugates will allow to obtain safely, cheaply and in unlimited quantities antigenic substances for production of COVID19 vaccine.
Product Description
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Horbаtiuk Oksаnа B.
Guzyk Mykhailo M.
Komisarenko Serhii V.
Korchynskiy Oleksandr H.
Krynina Olha I.
Romaniuk Svitlana I.
Siromolot Andrii A.
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2020-12-15
