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Information × Registration Number 0220U104802, 0120U104850 , R & D reports Title Development of combined therapy for severe Klebsiella pneumoniae-associated nosocomial infections to overcome the antibiotic resistance popup.stage_title Head Moshynets Olena V., Registration Date 28-12-2020 Organization Institute of Molecular Biology and Genetics of NAS of Ukraine popup.description2  The aim of the project is to develop a new treatment protocol for overcoming multiple resistance to antibiotics, in particular to β- lactams, in the leading causative agent of nosocomial infections with high mortality - multidrug-resistant strains of Klebsiella pneumoniae. For this, new activity of well known macrolide antibiotic azithromycin as an anti-biofilm agent in a combined antibacterial therapy will be studied. Specifically, an effectiveness of azithromycin in a combination with the antibiotic of last reserve but low effectiveness colistin to combat antibiotic resistance in MDR K.pneumoniae will be investigated. One more aim is to investigate whether azithromycin can increase a phenotypic sensitivity to β-lactam antibiotics. Pharmacological mitigation of β-lactam resistance in MDR K.pneumoniae would allow a development and implementation of the first national recommendations in treatment of K.pneumoniae infections. Product Description popup.authors Baranovsky Taras P Potochylova Viktoriia V Pokholenko Yanina O. Rydneva Kateryna L Iungin Olga S popup.nrat_date 2020-12-28 Close