Registration Number
0220U104802,
0120U104850
, R & D reports
Title
Development of combined therapy for severe Klebsiella pneumoniae-associated nosocomial infections to overcome the antibiotic resistance
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Head
Moshynets Olena V.,
Registration Date
28-12-2020
Organization
Institute of Molecular Biology and Genetics of NAS of Ukraine
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The aim of the project is to develop a new treatment protocol for overcoming multiple resistance to antibiotics, in particular to β-
lactams, in the leading causative agent of nosocomial infections with high mortality - multidrug-resistant strains of Klebsiella
pneumoniae. For this, new activity of well known macrolide antibiotic azithromycin as an anti-biofilm agent in a combined
antibacterial therapy will be studied. Specifically, an effectiveness of azithromycin in a combination with the antibiotic of last
reserve but low effectiveness colistin to combat antibiotic resistance in MDR K.pneumoniae will be investigated. One more aim
is to investigate whether azithromycin can increase a phenotypic sensitivity to β-lactam antibiotics. Pharmacological mitigation
of β-lactam resistance in MDR K.pneumoniae would allow a development and implementation of the first national
recommendations in treatment of K.pneumoniae infections.
Product Description
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Baranovsky Taras P
Potochylova Viktoriia V
Pokholenko Yanina O.
Rydneva Kateryna L
Iungin Olga S
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2020-12-28
