Registration Number
0220U104886,
0118U007364
, R & D reports
Title
Develop a technology for assessing and improving the control of bronchial asthma in adolescents
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Head
Rechkina Olena O,
Registration Date
30-12-2020
Organization
State organization "National Institute of Phthisiology and Pulmonology named after F.G. Yanovsky National academy of medical sciences of Ukraine"
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Object: 60 adolescents with bronchial asthma (BA) without exacerbation. Aim – to increase control of asthma in adolescents on the basis of new scientific data on the characteristics of the clinical course, functional tests and the life quality of patients. Methods – clinical, spirography, questioning, mathematical, statistical. The parameters of bronchial asthma (BA) affecting the quality of life (QL) of adolescents were established: the integrated indicator of total QL PAQLQ with a score of < 6 points correlated with IgE-dependent phenotype of mixed form of asthma with 2 or more concomitant extrapulmonary allergy can be considered as markers of risk of decrease in moderate QL. New data on the relationship between indicators of respiratory function with the adolescents asthma QL and developed a model for establishing indications for bronchodilation test with a combined short-acting bronchodilator (CB) in adolescents asthma, performed using linear regression equations with high accuracy of the forecast of the expected reaction of patients to the bronchodilation test with CB and allows to increase the accuracy of diagnosis of the asthma control level by 21,2 %, to prevent unnecessary costs for unreasonable examinations. A method for monitoring the level of asthma control in adolescents by bronchodilation tests with short-acting bronchodilators has been developed, which in controlled asthma can increase the detection of cases of "hidden" bronchospasm to 20,0 %. A new method for assessing the level of asthma control in adolescents, according to which in patients with an increase in FEV1 ≥ 12,0 %, established in the bronchodilator test with salbutamol use questionnaire PAQLQ and with an overall quality of life < 6 points perform an additional test with CB and FEV1 increase ≥ 12,0 % establish "hidden" bronchospasm, which allows to increase 1,8 times the accuracy of assessment of the level of asthma control. Sphere of application – pediatrics, pulmonology, allergology.
Product Description
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Kostromina Viktoriya P
Rechkina Olena O.
Rudenko Sehriy M
Stryzh Vira O
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2020-12-30
