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Information × Registration Number 0221U000214, 0120U105193 , R & D reports Title Anticoronavirus activity of water-soluble C60 fullerenes in the creation of new prototypes of prophylactic and therapeutic drugs: in silico, in vitro and in vivo screenings. popup.stage_title Head Prylutskyi Yurii I., Доктор фізико-математичних наук Registration Date 03-01-2021 Organization Taras Shevchenko National University of Kyiv popup.description2 The object of the study is the interaction of C60 fullerene with coronavirus SARS-CoV-2. The aim of the study was to determine the anticoronaviral activity of C60 fullerene. Research methods - atomic force microscopy, dynamic light scattering, molecular dynamics, docking. A literature search was performed and active target proteins were selected from the coronaviruses studied, including SAPRS-CoV-2 (RdRp and 3CLrgo) and cells of various organs sensitive to them (ACE2 and TMPRSS2) capable of binding to C60 fullerene. The design of potential complexes "C60-protein", in particular "C60-3CLrgo", in a simulated cellular environment using the methods of molecular dynamics and docking. It is shown that C60 fullerene can form a stable complex with the 3CLrgo protein of coronavirus SARS-CoV-2 and, thus, inhibit its functional activity. An aqueous colloidal solution of C60 fullerenes was prepared and characterized using the original ultrasonic technology, microscopic and spectroscopic methods.  Product Description popup.authors Gurmach Vasylʹ V. Zavalnyy Dmytro K. Platonov Maxim O. Prylutsʹka Svitlana V. Cherepanov Vsevolod V. popup.nrat_date 2021-01-03 Close