Registration Number
0221U000214,
0120U105193
, R & D reports
Title
Anticoronavirus activity of water-soluble C60 fullerenes in the creation of new prototypes of prophylactic and therapeutic drugs: in silico, in vitro and in vivo screenings.
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Head
Prylutskyi Yurii I., Доктор фізико-математичних наук
Registration Date
03-01-2021
Organization
Taras Shevchenko National University of Kyiv
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The object of the study is the interaction of C60 fullerene with coronavirus SARS-CoV-2.
The aim of the study was to determine the anticoronaviral activity of C60 fullerene.
Research methods - atomic force microscopy, dynamic light scattering, molecular dynamics, docking.
A literature search was performed and active target proteins were selected from the coronaviruses studied, including SAPRS-CoV-2 (RdRp and 3CLrgo) and cells of various organs sensitive to them (ACE2 and TMPRSS2) capable of binding to C60 fullerene. The design of potential complexes "C60-protein", in particular "C60-3CLrgo", in a simulated cellular environment using the methods of molecular dynamics and docking. It is shown that C60 fullerene can form a stable complex with the 3CLrgo protein of coronavirus SARS-CoV-2 and, thus, inhibit its functional activity. An aqueous colloidal solution of C60 fullerenes was prepared and characterized using the original ultrasonic technology, microscopic and spectroscopic methods.
Product Description
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Gurmach Vasylʹ V.
Zavalnyy Dmytro K.
Platonov Maxim O.
Prylutsʹka Svitlana V.
Cherepanov Vsevolod V.
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2021-01-03
