Registration Number
0221U100265,
0119U100563
, R & D reports
Title
Determination of the neurophysiological basis of cerebro-ophthalmological effects of small doses of irradiation
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Head
Loganovsky Kostiantyn M., Доктор медичних наук
Fedirko Pavlo A., Доктор медичних наук
Registration Date
04-01-2021
Organization
State Institution "National Research Centre For Radiation Medicine of National Academy of Medical Sciences of Ukraine"
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Aim: to determine the radiation-associated cerebro-ophthalmic effects of radiation in small doses according to different radiological
scenarios and their neurophysiological basis and to develop innovative radiation cerebro-ophthalmological diagnostic criteria. The object of the study was the features of neuropsychiatric, ophthalmological, and neurophysiological characteristics in the 95 irradiated persons: participants in the liquidation of the consequences of the Chornobyl accident (Chornobyl clean-up workers), persons irradiated in utero (n = 15), employees of the "Shelter" object (n = 25) and the comparison group - participants of Anti-Terrorist Operation / Joint Forces Operation (n = 25), taking into account the influence of ionizing radiation and the consequences of traumatic stress. Study methods: quantified neuropsychiatric, neuropsychological, ophthalmological, neurophysiological, statistical. The specific changes in the topographic parameters of the P300 component of visual cognitive potentials have been revealed, which may indicate dysfunction of the right parahippocampal area responsible for the perception and visualization of complex visual images. Significant bilateral growth of latent periods of N3 component with an accent in frontal and central parietal areas is revealed that can testify the disturbances of the structures involved in executive functions. For the first time, the presence of a correlation between the size of the macular focus in pixels and the latency of the P100 complex for the subjects (r = 0.56) was detected. It is shown that in the Chornobyl clean-up workers there are significant alterations of conjunctival haemomicrocirculation with a large proportion of vascular and perivascular changes: the conjunctival index remains significantly and substantially higher in the group with a higher dose load (10−200 sGy) compared to one with a lower dose load - 15.10 ± 0.82 compared with 6.57 ± 0.38, p <0.001.
Product Description
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Antypchuk Kateryna Yu
Babenko Tetyana F.
Hresko Maryna V
Dorichevska Raisa Yu.
Kreynis Georgiy Yu.
Kuts Kostiantyn V.
Loganovskaya Tatiana K
Masiuk Serhii V
Perchuk Iryna V
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2021-01-04
