Registration Number
0221U100369,
0119U100631
, R & D reports
Title
Research contribution of the system inflammation, oxidative processes and the most wide-spread persistent infection in development of comorbid conditions of the persons who were affected by Chornobyl accident
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Head
Ovsiannikova Liudmyla M., Доктор медичних наук
Chumak Anatolii A., Доктор медичних наук
Registration Date
05-01-2021
Organization
State Institution "National Research Centre For Radiation Medicine of National Academy of Medical Sciences of Ukraine"
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The object of the study was the metabolic and immune processes involved in the development of chronic inflammatory response and impaired pro-antioxidant balance in pathological conditions in individuals who have been exposed to damaging environmental factors. The purpose of the work was to evaluate changes in individual biochemical and immunological parameters in the comorbid course of chronic diseases of the hepatobiliary zone, cardiovascular system and / or dyscirculatory pathology of the brain in persons affected by the Chernobyl accident. Methods of research general clinical examination, instrumental studies (US of abdominal organs, esophagogastroduodenoscopy), biochemical, immunological, statistical, informational-analytical. The analysis of changes of individual biochemical and immunological parameters to determine the feasibility of their application in assessing the contribution of systemic inflammation, oxidative processes and most common persistent infections in the development of comorbidity of the victims due to the Chernobyl accident, in particular at the time of chronic disease, and/or dyscirculatory pathology of the brain. The manifestations of inflammatory reactions, disorders of lipid and carbohydrate metabolism, signs of cytolytic and cholestatic syndromes were diagnosed. Most patients were at risk of developing complicated cardiovascular pathology. Based on the results of a comprehensive analysis of clinical and laboratory changes, a group of indicators was outlined. They should be used to develop approaches to determine laboratory markers of adverse comorbid pathological conditions. At the next stage, the work should be aimed at accumulating a sufficient number of observations and conducting repeated surveys. The results of the work were published at two scientific forums.
Product Description
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Alokhina Svitlana M
Nosach Olena V.
Pleskach Oksana Ya.
Sarkisova Eleonora O.
Shyiko Tetiana O.
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2021-01-05
