Registration Number
0221U100443,
0118U001714
, R & D reports
Title
To determine the peculiarities of chemical and radiation factors genotoxic influence on radiotherapy cytogenetic effects in cancer patients in vivo and ex vivo
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Head
Maznyk Nataliia O., д.б.н.
Registration Date
05-01-2021
Organization
State Organization "Grigoriev Institute for Medical Radiologiy of the National Academy of Medical Sciences of Ukraine"
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Object of study: cytogenetic effects in cultured peripheral blood lymphocytes of cancer patients with various tumor localizations during therapeutic radiation exposure followed by chemotherapy. The aim: to assess the effect of previous chemoradiotherapy on the character of radiation- and chemical-induced cytogenetic effects during radiation therapy in vivo and ex vivo depending on the mutagenic factor and tumor localizations. Research methods and techniques: cytogenetic analysis of human blood cultured lymphocytes, statistical methods of data processing, microscopes Axioskop, Micros MC300X, Olympus CX41 and Olympus, system ASIS. Theoretical and practical results: the different pace of chromosome aberrations accumulation in groups of patients with various tumor localizations depending on the regimen treatment was found. The increase of radiation-induced aberrations from beginning to end of treatment in patients with lung cancer and less pronounced changes in these parameters in patients with head and neck tumors were demonstrated. Against the background of the absence of a clearly pronounced effect of chemotherapeutic treatment on the frequency of radiation-nonspecific chromatid type damages a dependence of these parameters on the tumor localizations was observed. The obtained data are necessary for correct assessing the impact of therapeutic irradiation on the chromosomal level. Novelty: the quantitative yield and quality range of cytogenetic damage in lymphocytes of patients with lung cancer and head and neck cancer before and during radiation therapy in the presence of previous chemoradiation therapy were identified. The effectiveness of implementation: timely correction of the course of radiation therapy. Area of application: radiobiology, radiation therapy, radiation medicine.
Product Description
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Artiukh Serhii V.
Bilozor Nataliia V.
Haiseniuk Larysa O.
Hukova Inna M.
Dashkova Svitlana A.
Zabobonina Larysa V.
Kolpakova Liudmyla K.
Myrna Olha M.
Niemykina Nadiia V.
Pshyshevska Liudmyla A.
Sviatenko Nina I.
Sypko Tetiana S.
Slobodianiuk Olha V.
Starenkyi Viktor P
Cherkasko Liudmyla V.
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2021-01-05
