Registration Number
0221U100849,
0115U006647
, R & D reports
Title
The State of the microcirculative-tissue, cell and endocrine factors in endometrial and placental complex hyper- and hypoplastic processes and etiopathogenic directions of their correction and therapy
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Head
Andriyevskiy Olexandr H., Доктор медичних наук
Registration Date
10-01-2021
Organization
Odessa National Medical University
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The object of this study - 458 patients of late reproductive, peri-, and postmenopausal age. Of which the control group consisted of 133, the group with endometrial hyperplastic processes - 173, the group with atypical endometrial hyperplasia - 152 patients. The aim of the study is to reduce the frequency of development and progression of proliferative conditions and atypical forms of endometrial tissue pathology by implementing a set of scientifically grounded measures taking into account the state of microcirculatory tissue, cellular and endocrine factors. Research methods are general clinical, clinical-laboratory, clinical-instrumental, biochemical, histological, immunohistochemical, molecular genetic, statistical. Based on the research, a change in the activity of the endometrial receptor field on the background of decreased apoptosis (Ki67, p53, bcl-2) with increasing hypoxic state in the perimenopausal period (Hif-1α). A preventive and corrective program for the development of pathological conditions of the endometrium has been established and developed.
Product Description
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Andriievskii Oleksandr H.
Artyomenko Volodymyr V.
Gladchuk Vasyl I.
Derishov Vasyl V.
Derishov Sergiy V.
Yermolenko Tetana O.
Zhovtenko Olesia V.
Zubarenko Konstantin O.
Kozhukhar Аnna
Kozhukhar Аnna V.
Manasova Gulsym S.
Mnikh Liudmila V.
Nadvorna Olha M.
Nastradina Natalya M.
Khodorchuk Konstantin V.
Shablii Tetiana P.
3. Shapoval Mykola V.
Shpak Igor V.
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2021-03-17
