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Information × Registration Number 0221U100922, 0116U000109 , R & D reports Title To investigate mechanisms of cellular, humoral immunity, endocrine factors and metabolic changes during physiological and pathological processes in the organism of birds in the reproductive period. popup.stage_title Head Muzyka Nataliia M., Кандидат ветеринарних наук Registration Date 11-01-2021 Organization State poultry research station popup.description2  It was found that the intensity of immunity to the diseases against which vaccination was carried out during the six months of the reproductive period was 100%. The use of immunostimulating drugs in chickens before vaccination allowed to obtain more intense immunity to diseases - antibody titers were higher by 1-1.5 log. However, in chickens affected by stress factors (nutritional, technological), antibody titers were lower by 1-2 log. The study of metabolic indicators in the body of chickens did not reveal a significant difference in the content of hemoglobin in the blood, protein, lipids, cholesterol in the serum. The content of circulating immune complexes was within the physiological norm. In biochemical studies it was found that the bactericidal activity of serum of chickens of the experimental groups increased by 10-12%, also increased the number of erythrocytes, hemoglobin, total protein. The increased amount of globulins, especially gamma- (33% more than in the control group), indicates an intensive process of antibody formation after vaccination. The obtained knowledge about the mechanisms of formation of cellular and humoral immunity, endocrine factors with the use of associated vaccines will simplify the control of the general condition of poultry, minimize the effects of stress on poultry, increase safety by 2.8%, increase antibody levels by 10.5% Product Description popup.authors Bondarenko Angela L. Muzyka Nataliya М. Nalyvaiko Liudmyla I. popup.nrat_date 2021-01-11 Close