Registration Number
0221U101341,
0120U104808
, R & D reports
Title
Center for investigation of neutrophil exctracellular traps involvement in initiating tissue pathologies in vivo
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Head
Bilyy Rostyslav O., Доктор біологічних наук
Registration Date
20-01-2021
Organization
Danylo Halytsky Lviv National Medical University
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Neutrophil extracellular traps (NETs) were realized to contribute to tissue pathologies only few years ago. We have demonstrated (in collaboration) that NETs are involved in: blood occlusion during acute inflammation (Science,2017), kidney failure (JASN,2019); initiation of gallstones (Immunity,2019). We also showed that NETs are beneficial when isolating areas of necrosis (Front.Immunology,2016) or boosting of immune response for novel vaccine adjuvants (Materials Today,2019). NETs are recognized as main lung damager at COVID (Front.Pharm.,2020). Our preliminary data suggests at least 3 conditions where NETs can be important in initiating pathology: liver damage at NAFLD; brain damage during malaria and gout; predetermining lung damage (including COVID) upon soot inhalation. These 3 hypotheses will be tested within the project, as well as needed infrastructure will be established. The latter include small animal in vivo imaging device and facilities, not currently available in Ukraine
Product Description
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2021-01-20
