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Information × Registration Number 0221U101365, 0117U007185 , R & D reports Title Scientific substantiation of the choice of diagnostic methods and complex treatment of patients with malignant neoplasms in the modified tissue of the thyroid gland popup.stage_title Head Karachentsev Yuri I., Доктор медичних наук Registration Date 20-01-2021 Organization State Institution “V.Ya.Danilevsky Institute of Endocrine Pathology Problems of Academy of Medical Sciences of Ukraine” popup.description2 Object: malignant neoplasms in the altered thyroid tissue (thyroid). Objective: based on the study of clinical and pathomorphological, genetic features of the development and course of malignant neoplasms in the altered thyroid tissue to optimize the diagnosis, surgical tactics and strategy of postoperative treatment. Methods: general clinical, enzyme-linked immunosorbent assay, sonographic, pathomorphological, methods of formal genetics, statistical. In the clinic of IPEP NAMS for the period 2008-2020 2138 patients with thyroid cancer (thyroid cancer) were operated. The revealed significant predominance of papillary thyroid (PID) (88.3%) over follicular thyroid (PID) (8.6%) may indirectly indicate the absence of iodine deficiency in the Left Bank Ukraine. Pathomorphological analysis of the combination of thyroid cancer with other thyroid diseases revealed that in 28% thyroid carcinomas were observed as an independent disease, in 72% they were combined with other thyroid pathology. PD is most common on the background of autoimmune thyroiditis (AIT) and colloid goiter, significantly less often with follicular adenoma. HRT occurs equally on the background of colloid goiter and follicular adenoma (36% and 35%, respectively), significantly less often on the background of AIT and diffuse toxic goiter. There was a significant decrease in the aggressiveness of the thyroid gland on the background of AIT and colloid goiter. Invasion outside the thyroid gland was significantly less common in thyroid disease on the background of AIT and colloid goiter. Metastases to the lymph nodes of the neck were significantly less common in thyroid cancer on the background of colloid goiter. Background pathology of the thyroid gland does not reduce the aggressiveness of the thyroid gland, on the contrary, significantly less common invasion of the thyroid capsule in the thyroid gland as an independent disease compared with FR on the background of AIT. Product Description popup.authors popup.nrat_date 2021-01-20 Close