Registration Number
0221U101401,
0118U004009
, R & D reports
Title
Synthesis of new potentially active compounds based on urea and thiourea derivatives, prediction of their bioactivity.
popup.stage_title
Head
Avdeenko Anatoly P., Кандидат хімічних наук
Registration Date
20-01-2021
Organization
Donbass State Engineering Academy
popup.description2
Object of research: N-substituted-N'-acylthioureas and products of their interaction with dinucleophiles. Objective of research: study of possible biological activity of new derivatives of urea and thiourea using the PASS program. Research methods: physical and chemical methods for the investigation of compounds: IR, NMR 1H, NMR 13C spectroscopy, elemental analysis. Theoretical and practical results: The PASS program was used to analyze the potential biological activity of the synthesized compounds. It was found that the synthesized compounds can show antidepressant, hemorheological, antiplatelet, anti-firing, analgesic and antioxidant activities. Among the synthesized compounds the substances with effect on microsomal oxidation in the liver were also found. Therefore these compounds are good objects for further research to find new effective drugs, pesticides. Some regularities of the structure-activity dependence in synthesized compounds have been established. Efficiency of introduction: new derivatives of urea and thiourea are potential biologically active compounds and can be used as drugs, pesticides. Application area: in the general and special courses of organic chemistry in universities. The products obtained in this work can be tested as new drugs.
Product Description
popup.authors
Avdeenko Anatoly P
Konovalova Svetlana O
popup.nrat_date
2021-01-20
