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Registration Number

0221U101490, 0116U001415 , R & D reports

Title

To study the biochemical mechanisms of formation and regulation of the cell compartment and humoral immunity in animals in norm and pathology.

Head

Vishchur Oleh I, Доктор ветеринарних наук

Registration Date

21-01-2021

Organization

Institute of Animal Biology of NAAS

Description

The possibility of using emulsions and ointments "Antimast", made on the basis of bee raw materials, for the treatment of subclinical forms of mastitis is shown. Studies have shown the inhibitory effect of drug factors on the processes of LP and OMP and their stimulating effect on the activity of antioxidant enzymes in the blood of cows with subclinical mastitis. The proposed treatment regimens for cows with various forms of mastitis, using the drug "Limanin" and a complex liposomal drug based on ethylthiosulfanilate (ETS) helped to restore metabolic homeostasis and immune potential. The possibility of using immunomodulatory drugs - yeast Saccharomyces cerevisiae or BPS-44 - for vaccination of broiler chickens has been theoretically and experimentally substantiated. Developed a new complex liposomal drug "Nero" parenteral administration of which to young piglets helped to increase factors non-specific resistance and antioxidant protection of their body and had a positive effect on the formation of adaptability. A comprehensive study of the indicators characterizing the hematological profile, the state of the immune and antioxidant defense systems in broiler chickens during their cultivation under the action of the synbiotic drug "Enteronormin", activated by an aqueous solution of iodine and selenium. The normalizing effect of intramuscular administration of liposomal drug "Butaselmevit" and feed additive "Butaselmevit-plus" on the formation of the immune response and adaptability in laboratory animals under the conditions of modeling the stress response is proved. Tthe composition and scheme of application of modern immunomodulatory drugs (in the form of liposomal emulsions, symbiotic agents and feed additives) for activation and rehabilitation of reactions of natural and adaptive immune protection in animals and poultry according to norms and pathologies are developed

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Broda Nataliia A
Kychun Igor V
Martyshchuk Tetiana V
Masyuk Maria B
Matlakh Iryna Yo
Matiukha Iryna O
Mudrak Dariia I
Ohorodnyk Nataliia Z
Ratskiy Markian I
Romanovych Mykola M
Smolianinov Kostiantyn B
Sobko Halyna V
Fialkovskyi Pavlo M
Fedoryshyn Sofiia I
Yamroz Viktor Yo
Yasnyskyi Roman S