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Registration Number

0221U101750, 0118U000196 , R & D reports

Title

To study the efficiency of regenerative processes in bone and cartilage tissues using biocompatible compositions using three-dimensional frameworks for implantation in plastic operations in otolaryngology

Head

Zabolotniy Dmytro I, Доктор медичних наук

Registration Date

25-01-2021

Organization

State Institution "Professor OS Kolomiychenko Institute of Otolaryngology of the National Academy of Medical Sciences of Ukraine"

Description

Improvement of technology and creation of three-dimensionally structured composite materials based on polymerized chitosan after its dissolution in organic acids and the addition of bioceramic materials, as well as biopolymers and stimulants in accordance with the peculiarities of the functioning of bone and cartilaginous tissues made it possible to obtain implant samples that do not cause toxic effects when cultured with of grafted cells in vivo, can effectively enhance the degree of adhesion and proliferation of grafted cells in culture, improve the functionality of the resulting composite material. Morphological, histochemical and electron microscopic studies after implantation into cartilage and bone tissue of rats in vivo indicate that the improvement of the chemical and structural organization of materials for implantation contributes to biological interaction, resorption, successful penetration and internalization of factors important for cartilage and / or bone metabolism, improvement of vascularization, the course of reparative processes in general. The results of preclinical studies made it possible to develop new technologies for the use of three-dimensionally structured inorganic-organic composites based on bioceramics, chitosan after modifying them by processing biological factors and stimulants important for tissue functioning, taking into account the specificity of tissues and organs for clinical trials and introduction into clinical practice in reconstructive surgery. 

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