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Information × Registration Number 0221U101795, 0119U100659 , R & D reports Title Predioction and prevention of postoperative complications on the background of severe comorbid state in liver failure popup.stage_title Head Kutovyi Oleksandr B., Registration Date 25-01-2021 Organization State institution "Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine" popup.description2 The aim of the work is to investigate the diagnostic value of laboratory blood biomarkers - alanine aminotransferase, aspartate aminotransferase, oxyproline and prothrombin time in comparison with morphological indicators for diagnosis of the degree of liver fibrosis in patients with comorbid course of non-alcoholic steatohepatitis (NASH)in combination with obesity and chronic calculous cholecystitis.The data of 22 patients with NASH in combination with obesity and chronic calculous cholecystitiswas analyzed by laboratory and morphological indicators. There were 6 (27.2%) men and 16 (72.8%) women among the patients. Liver biopsy was performed intra-operatively on performing surgical treatment of calculus cholecystitis. METAVIR and Е. Brunt criteria were used in the histological diagnosis of NASH, as well as for determination of the stage of liver fibrosis (LF). Hepatic tissue fibrogenesis was assessed by serum values of total (OPT), free (OPF) and protein-bound (OPB) oxyproline, activity of indirect fibrosis markers - alanine aminotransferase (ALT), aspartate aminotransferase (AST), AST / ALT ratio and prothrombin time (РТТ). As a mathematical tool for modeling, stepwise discriminant analysis was used.Fibrosis of the first stage (F1) was observed in 5 (22.7%) patients, the second stage of fibrosis (F2) - in 7 (31.8%), F3 stage of fibrosis - in 10 (45.5%) patients. Analysis of the morphological study of liver biopsy samples in examined patients with NASH indicates that established histological changes combine the signs of fatty and protein degeneration of hepatocytes, inflammation and necrosis in the lobules. Among the indicators included in the mathematical model the highest diagnostic significance can be attributed to the AST / ALTratio (F = 9.03; p = 0.003) and the level of OPF (F = 5.67; p = 0.016), whereas OPB level has the lowest value (F = 2.94; p = 0.086). Evaluation of the accuracy of the method for determining of the LF phase based on the proposed algorith  Product Description popup.authors Hrechanyk Mariia M Kuriata Olexandr V Kushnir Yulia S Rodynska Galyna O Philippova Olexandra Yu popup.nrat_date 2021-01-25 Close