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Information × Registration Number 0221U101867, 0120U100158 , R & D reports Title Search for sorbents to immobilize lactobacilli cells popup.stage_title Head Danylenko Svitlana G., Доктор технічних наук Registration Date 26-01-2021 Organization Іnstitute of Food Resources popup.description2 An important factor in the effectiveness of probiotic therapy is the survival of cells in the gastrointestinal tract and their integration into the intestinal biofilm. Therefore, the creation of combined drugs with immobilized cultures has become relevant. The purpose of this work was to study the possibility of creating immobilized drugs based on lactobacilli. Object of research: sorbent-probiotic complex. Subject of research: survival of lactobacilli after sorption on enterosorbents based on highly dispersed silica. Research methods: microbiological. It was determined that immobilization on enterosgel caused less cell death than on finely divided dry powder Sillard P. It was found that the survival of immobilized and non-immobilized samples of Lactobacillus plantarum after storage for 30 days in a refrigerator at +4 - 32% decreased. Freeze-drying resulted in a 2-fold reduction in survival. Rational ratios of "sorbent-suspended culture" after sorption were determined: from 0.1 g / cm3 to 0.15 g / cm3 of culture suspension for dry and wet enterosgel. The positive effect of the addition of dried bacterial cellulose on the survival of cells sorbed and unsorbed on enterosgel was found to be 20-30%, which requires further research.   Product Description popup.authors Anisimova Liudmyla V. Danylenko Svitlana H. Marynchenko Lolita V. Potemska Oksana I. Khonkiv Myroslav O. Shchehliuk Nadiia V. popup.nrat_date 2021-01-26 Close