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Registration Number

0221U101883, 0118U005470 , R & D reports

Title

Investigation of functional plasticity of macrophages under the conditions of application of means of chemo- and biotherapy of cancer

Head

Didenko Gennadii V., Кандидат біологічних наук

Registration Date

26-01-2021

Organization

R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine

Description

 During the growth of Lewis lung carcinoma tumor, a number of parameters expressing functional activity of macrophages was defined (cytotoxic activity, production of NO, arginase, exogenous peroxidase) characterizing theirs immunoregulatory pro- or antitumor reactions. It was shown for the first time that in early stages of tumor growth macrophages, despite of the anatomical niche, are presented as cells possessing antitumor properties (M1); in more advanced stages macrophages gradually polarize towards displaying protumoral features M2 phenotype. These changes were more apparent for the alveolar macrophages and correlated with the metastases. The obtained data open the prospects to strategies applying the phenomenon of macrophages plasticity for reducing the metastasis risk.

Product Description

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Voeykova Iryna M.
Didenko Gennadii V.
Kruts Olena O.
Fedosova Nataliia I.
Cheremshenko Nadiia L.
Chumak Alina V.