Registration Number
0221U102423,
0116U002932
, R & D reports
Title
Pharmacological and pharmacoeconomic study of the application of medicines with antioxidant activity under the conditions of damaged kidneys and digestive system
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Head
Herush Oleh V,
Registration Date
02-02-2021
Organization
HSEE of Ukraine "Bukovinian State Medical University"
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Hepatoprotective activity of new drugs of complex herbal capsules "Hepafisan" and granules "Hepatropin" on various lycoinduced (paracetamol and caused by tuberculostatics) models of hepatitis was established for the first time. It is proved that in the mechanism of hepatoprotective action of the studied drugs their ability to increase the activity of antioxidant protection, inhibit the processes of lipid peroxidation, reduce their damaging effect on hepatocytes, and reduce the severity of cytolytic and inflammatory processes plays a significant role. The specific activity and harmlessness of the new combined oil phytoextract "Oleosil" have been proved, and its hepatotropic effect has been established.
As a result of the conducted experimental researches convenient methods of synthesis of derivatives of [(5-formyl-1H-imidazol-4-yl)] thioacetic acids are offered. Data on the biological potential of the synthesized compounds were obtained and it was found that they are characterized by pronounced hypoglycemic activity and moderate antimicrobial properties. Extended data on the toxicological characteristics of nanochrome citrate. The dose-dependent effect of nanochrome citrate on the indicators of excretory function of the kidneys is specified. It has been shown that the use of quercetin (corvitin and lipoflavone) and lipin for the treatment of animals with acute renal failure helps to restore fibrinolytic potential and proteolytic activity.
Product Description
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Bogdan Nataliia S
Horoshko Oleksandra M
Hudz Nadiia А.
Korovenkova Oksana M
Palamar Alina O
Rovinskyi Oleksandr O
Sadohurska Katyeryna V
Tkachuk Olesia Yu
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2021-02-02
