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Information × Registration Number 0221U102923, 0116U000791 , R & D reports Title Genetic and molecular mechanisms of course and substantiation of differential treatment measures in children with multifactorial diseases. popup.stage_title Head Banadyha Nataliia V, Registration Date 11-02-2021 Organization Ternopil National Medical University named after I. Gorbachevsky of the Ministry of Health of Ukraine popup.description2  GDR report: 81p., 5 tables., 7 fig., 41 source. BRONCHIAL ASTHMA, GENOTYPE, PHENOTYPES, THERAPY, VEGETO-VASCULAR DYSFUNCTIONS, LYME DISEASE, SEROLOGICAL EXAMINATIONS. The study included 239 children, including 101 patients with bronchial asthma, 98 children with vegetative-vascular dysfunction, and 40 patients with Lyme disease. The purpose of the work is to increase the effectiveness of treatment of children with multifactorial diseases, taking into account the genetic and molecular mechanisms of occurrence and to formulate preventive measures. Research methods - clinical (assessment of initial autonomic tone by clinical symptoms), laboratory (general analysis of blood and urine), biochemical (total protein, creatinine, urea, acute phase inflammation), molecular genetic (polymorphism of G308A TNF? ADRG2 Rgs Arg genes) 1042713 and TNF? (G308A) rs1800629, quantification of TNF? parameters), bacteriological (serological reactions for detection of Lyme borreliosis), instrumental (spirography, ECG, UCP radiography, Echo-cardioscopy, cardiogenesis Kerdo); assessment of control of bronchial asthma according to the questionnaire (ACT, CACT). According to molecular genetic analysis, a relationship was established between the ADR?2 genotype and the severity of the course of asthma: in persistent - Arg16Gly, in intermittent - Gly16Gly of the ADR?2 gene. When comparing the diagnosed polymorphic genotypes of asthma depending on the period of the disease, it was found that GG / Gly16Gly ADR?2 variant is most often diagnosed among patients with achieved control over the course (in 54.55% of cases) and in remission of asthma (39.13%). This gives reason to believe that it is in patients with this genotype the most favorable course of asthma and there is a high probability of seizure prevention. At the same time, the GG / Arg16Gly polymorphic variant occurred in children with almost the same frequency in the period of exacerbation (25.37%) and remission of the disease (21.74%). Product Description popup.authors popup.nrat_date 2021-02-11 Close