Registration Number
0221U103281,
0116U000250
, R & D reports
Title
To study the dynamics of the impact of organic products on the molecular genetic and humoral factors of the natural resistance of farm animals and poultry
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Head
Herilovych Anton P,
Registration Date
17-02-2021
Organization
National Scientific Center Institute of Experimental and Clinical Medicine
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The aim of the study is to establish the dynamics of immunocompensatory reactions and gene expression of immune response mediators under the action of drugs based on serum globulins with the addition of aquachelates of iron nanoparticles, metal salts and probiotics and feed additives based on silkworm pupae.
Research methods - clinical, biochemical, statistical.
It is proved that the developed probiotic-nanomethaloglobulin preparation (PNMGP) on the basis of bovine serum globulins with the addition of aquachelates of iron nanoparticles, metal salts and probiotics is harmless, increases the activity of nonspecific immunity to 20% and indicates by 50.0%, affects the functional state of the liver and kidneys of birds. It induces the expression of genes encoding the cytokines IL-17α, IL-2, IFN-γ.
The content of biologically active substances, macro- and microelements in the initial biological mass of the silkworm pupa (LSW) and its extracts was determined. The safety and biological effect of experimental samples of feed additives from LVH on the body of rats were established.
The positive effect of the developed feed additive based on silkworm pupae (CD LSW) on body weight gain of broiler chickens, in particular with vaccinations against Newcastle disease, hemoglobin synthesis and leukocyte count, as well as the state of nonspecific humoral immunity.The drug enhanced specific immunity after vaccination with Newcastle disease vaccine by 2 log2. and gene expression of cytokines such as IL-17α, IL-2, IFN-γ.
Based on the obtained results, normative documentation (dossier) for probiotic nanometalloprotein preparation was prepared, the technology of making lyophilized feed additive based on silkworm pupae, regulations for its use in poultry farming, and experimental series of these drugs were developed.
Product Description
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Isichenko Nаtаliia V.
Boiko Viktoria S
Vovk Serhii I
Kovalenko Larysa V
Litvin Viktor M.
Muzyka Denys V.
Rudenko Olena Olena P
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2021-02-17
