Registration Number
0221U103421,
0120U101227
, R & D reports
Title
Mechanisms of development and compensation hypoxic and oxidative tissue damage in neurodegenerative and metabolic disorders
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Head
Mankovska Iryna M., Доктор медичних наук
Portnichenko Alla H., д.мед.н.
Registration Date
20-02-2021
Organization
Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine
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Experimental and clinical studies have established the mechanisms of prophylactic and therapeutic effects of pharmacological drugs of antioxidant and antihypoxic action in diabetes mellitus, Parkinson's disease, cerebral hypoperfusion, based on the correction of mitochondrial and endothelial dysfunction, oxidative stress, stress of the endoplasmic reticulum, changes in the activity and expression of protective proteins and metabolic regulators. Methods of non-pharmacological correction (interval hypoxic and hypoxic-hyperoxic training, polychrome bioregulation method) have been developed, and systemic and molecular mechanisms of their favorable action were established in patients with metabolic syndrome, early stages of type 2 diabetes and Alzheimer's disease, as well as in severe hypoxic lesions, exercise, extreme influences in Antarctic winterers.
Product Description
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Aliyev Rufat B.
Babicheva Victoria V.
Bakunovsky Оlexander M.
Baranovska Iryna O.
Bratus Larysa V.
Vasylenko Maryna I.
Harmatina Olha U.
Gonchar Olga Olga O.
Dubova Maria H.
Zavgorodniy Mykola O.
Kozlovskaya Maria G.
Korolʹova Yelyzaveta V.
Moiseenko Yevhen V.
Ponomareva Irina V.
Portnichenko Volodymyr I.
Putiy Yuliya V.
Rozova Kateryna V.
Serebrovska Tetiana V.
Sidorenko Alla M Alla M.
Tymoshenko Kateryna R.
Topchanyuk Lubomir Y.
Tsapenko Petro K.
Shapovalova Anna S.
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2021-02-20
