Registration Number
0221U103526,
0118U004274
, R & D reports
Title
Study of the prevalence, features of clinical manifestations, mechanisms of progress and development of the treatment approaches of nervous system affection in patients with diabetes mellitus, metabolic syndrome and obesity.
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Head
Mankovsky Boris M., Доктор медичних наук
Registration Date
22-02-2021
Organization
State Scientific Institution "Center for Innovative Medical Technologies of the NAS of Ukraine"
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At the stage of the study, patients with newly diabetes mellitus (DM), prediabetes and diabetes mellitus type 2 were examined to determine the risk factors for vognitive impairment, the presence of cardiac autonomic neuropathy(CAP), diabetic peripheral neuropathy, state of the antioxidant system, the level of mRNA HIF-1 and BDNF and the effect of metformin on these parameters, the study of the incidence of depressive disorders in patients with obesity and liver fibrosis.
During the reporting period, the results were presente at scientific and practical conferences at the international and domestic levels. Summarizing the results of this study, we can conclude that cognitive impairment is a common complication of both pre-existing diabetes mellitus and newly diagnosed diabetes mellitus2. Thus, for type 1 diabetes is from 54.5% to 63.6%, among patients with type 2 diabetes - from 20.0% to 96.7%, for newly diagnosed - 8.3% to 96.7 % depending on the tests performed to assess cognitive impairment.
Metformin treatment in patients with newly diagnosed diabetes mellitus has been show to improve memory function, executive function, reduce DPN, increase catalase, glutathione peroxidase, BDNF, and decrease HIF-1 mRNA. After 10 days of treatment with alpha-lipoic acid (ALA) in patients with diabetes mellitus, the total score of all CVT probably decreased and the frequency of the expressed clinical form of CAN decreased by 5.8%.
Further research in this direction is promising given the possibility of improving preventive measures.
Product Description
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BAKA OLENA M
ZHERDOVA NADIIA M
Orlyk Olga S
Saienko Ianina A
SAKHAROVA YULIIA V
STEPURA OLENA A
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2021-02-22
