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Information × Registration Number 0221U103814, 0118U001190 , R & D reports Title Investigate the involvement of inflammas in the pathogenesis of psoriasis and the possibility of direct effect on their functions popup.stage_title Head Білозоров Олексій Павлович, Registration Date 25-02-2021 Organization SE "Institute of Dermatology and Venereology of NAMS of Ukraine" popup.description2 The object of study is the pathogenesis of psoriasis. The purpose of the study is the investigation of the involvement of inflammasomes in the pathogenesis of psoriasis and the possibility of targeted effects on their functions. Methods: clinical, molecular biological, statistical. The methods for studying the polymorphisms of rs878329 NLRP1 C/G and rs10484554 HLAC C/T alleles have been developed. The association of the HLA-Cw*06 gene and the T allele of the rs10484554 HLAC C/T gene polymorphisms with the psoriasis was revealed. It was found that in HLA-B*27 gene-positive patients the incidence of arthropathy was (66,7 ± 9,67) % which allows to use this criterion to predict the development of arthropathic psoriasis. There is a tendency to increase the relative number of carriers of allele I of the TLR1-I602S gene polymorphism. The correlation between the SPINK5 G1258A gene polymorphism and the PASI index indicates that the A allele of the SPINK5 gene contributes to less generalized and severe skin lesions. Decreased activity of the SPINK5 protease inhibitor may contribute to the development of psoriatic arthropathy, as evidenced by the correlation between the SPINK5 G1258A gene polymorphism and psoriatic arthritis. The association of the A allele of the SPINK5 G1258A gene polymorphism simultaneously with the active I allele of the TLR1 I602S polymorphism is observed mainly in patients with arthropathic psoriasis. Patients showed signs of a significant increase in the inflammasome activity. The positive correlation between the presence of the active allele of the rs878329 NLRP1 C/G gene polymorphism and the frequency of psoriasis relapses indicates the participation of inflammasomes in the development of exacerbations of psoriasis. Pharmacological inhibitors targeted at the state of inflammasomes may in the future be considered as therapeutic agents for the treatment of psoriasis. Product Description popup.authors Gavrylyuk Oleksandra A. Hoidenko Nataliia I Holub Hanna P Holubko Serhii P Zelenska Anna D Miliutina Olena Yo. Mashtakova Iryna O Oliinyk Iryna O Pyatykop Inna O Sokol Oksana A. Stulii Olga M popup.nrat_date 2021-02-25 Close