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Registration Number

0221U104342, 0119U100340 , R & D reports

Title

Promising molecular tools based on natural and synthetic (carbo) heterocycles to solve problems of chemistry, medicine, industry.

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Head

Khylia Volodymyr P.,

Registration Date

15-03-2021

Organization

Taras Shevchenko National University of Kyiv

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 The object of research is N-, O-, S-containing (carbo) heterosystems. Purpose - Development of new synthetic methodologies for designing carbocyclic and heterocyclic compounds as promising molecular tools, methods for the synthesis of analogues of structurally similar to natural compounds and / or known drugs, research of chemical transformations, structural features, spectral characteristics, physicochemical properties to create new practically useful substances and materials. Research methods - methods of synthesis of model organic compounds, heterocyclic compounds; NMR, IR, UV, fluorescence spectroscopy; mass and chromato-mass spectrometry; synthesis methods under high pressure and in an inert atmosphere; X-ray diffraction and elemental analysis, in silico, in vitro and in vivo screening. For the needs of medical chemistry, methods for the synthesis of flavonoid derivatives, β-keto (amino) -γ (δ) -sults, azolo [a] pyridine, fluorine-substituted derivatives (carbo) of heterocycles and spirocycles have been developed. Synthesized linear and angular getarylflavonoids modified with amino acid residues. Synthetic possibilities of application of boron derivatives in C – C cross-coupling reactions have been studied. Developed: synthetic methodology for introduction of prenyl grouping into neoflavone nucleus, strategy of using enaminoketones in heterocyclization reactions; methods of regioselective synthesis of condensed pyridine-α (γ) -carboxylates. For diazepinone derivatives, tissue respiration and oxygen-dependent biosynthetic processes in rat liver were studied.

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Horichko Mar'yan V.
Gorbulenko Nataliia V.
Hryhorenko Oleksandr О.
Dobrydnev Olexey V.
Moskvina Viktoria S.
Potikha Lyudmyla M.
Tarasiuk Taras M.
Schokol Tetyana V.
Shtanova Lidiya Ya.

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2021-03-17