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Information × Registration Number 0221U104342, 0119U100340 , R & D reports Title Promising molecular tools based on natural and synthetic (carbo) heterocycles to solve problems of chemistry, medicine, industry. popup.stage_title Head Khylia Volodymyr P., Registration Date 15-03-2021 Organization Taras Shevchenko National University of Kyiv popup.description2  The object of research is N-, O-, S-containing (carbo) heterosystems. Purpose - Development of new synthetic methodologies for designing carbocyclic and heterocyclic compounds as promising molecular tools, methods for the synthesis of analogues of structurally similar to natural compounds and / or known drugs, research of chemical transformations, structural features, spectral characteristics, physicochemical properties to create new practically useful substances and materials. Research methods - methods of synthesis of model organic compounds, heterocyclic compounds; NMR, IR, UV, fluorescence spectroscopy; mass and chromato-mass spectrometry; synthesis methods under high pressure and in an inert atmosphere; X-ray diffraction and elemental analysis, in silico, in vitro and in vivo screening. For the needs of medical chemistry, methods for the synthesis of flavonoid derivatives, β-keto (amino) -γ (δ) -sults, azolo [a] pyridine, fluorine-substituted derivatives (carbo) of heterocycles and spirocycles have been developed. Synthesized linear and angular getarylflavonoids modified with amino acid residues. Synthetic possibilities of application of boron derivatives in C – C cross-coupling reactions have been studied. Developed: synthetic methodology for introduction of prenyl grouping into neoflavone nucleus, strategy of using enaminoketones in heterocyclization reactions; methods of regioselective synthesis of condensed pyridine-α (γ) -carboxylates. For diazepinone derivatives, tissue respiration and oxygen-dependent biosynthetic processes in rat liver were studied. Product Description popup.authors Horichko Mar'yan V. Gorbulenko Nataliia V. Hryhorenko Oleksandr О. Dobrydnev Olexey V. Moskvina Viktoria S. Potikha Lyudmyla M. Tarasiuk Taras M. Schokol Tetyana V. Shtanova Lidiya Ya. popup.nrat_date 2021-03-17 Close