Registration Number
0221U105883,
0120U104294
, R & D reports
Title
The influence of antiviral and thrombolytic drugs on the model membranes of viral particles and eukaryotic cells.
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Head
Dovbeshko Galyna I., д.ф.-м.н.
Registration Date
07-09-2021
Organization
Institute of Physics of National Academy of Sciences of Ukraine
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Object:.model membranes of viral particles, synaptosomes, drugs remdesivir and ticagrelor.
Aim: To investigate molecular mechanisms of action of amphiphilic drugs on lipid membranes of viral particles and cells infected with viruses, their mechanisms of sensitivity to membraneotropic drugs. Evaluation of the possibility of selective action on viral membranes using membrane-tropic drugs and the design of new drugs ..
Methodologies: The model objects will be: strongly curved artificial membranes liposomes, artificial lipid bilayers, membrane membranes of nerve cells, artificial liposomes. The research will be carried out by IR and Raman spectroscopy, confocal microscopy, fluorescent membrane probes, computer modeling by molecular dynamics.
Novelty: For the first time explored the influence of membraneotropic drugs on physical characteristics, parameters of structural organizations of lipid membranes, similar in composition, physical properties to viral membranes and plasma membrane of human cells, its prospects for antiviral therapy, the ability to achieve selectivity of membraneotropic action on the membrane.
During the first stage:
1.1 Obtained data on changes in the structural parameters of membranes after incorporation of drugs in silico.
1.2 Obtained data on the change of dynamic parameters of membranes after incorporation of drugs in silico.
1.3 Obtained data on the structural parameters of model membranes before and after incorporation of drugs in vitro
1.4 Obtained data on the structural parameters of model membranes before and after incorporation of drugs in vitro
1.5 Obtained data on the structural parameters of model membranes before and after incorporation of drugs in vitro
1.6 Obtained data on structural rearrangement and aggregation of model membranes before and after incorporation of in vitro preparations.
Product Description
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Yesylevskyy Semen Oleksandrovych
Barabash Yurii Markovych
Borysova Tetyana Oleksandrivna
Hnatyuk Olena Petrivna
Dovbeshko Galyna Ivanivna
Krisanova Natalia Valeriivna
Olenchuk Maryna Volodymyrivna
Panas Ihor Dankovych
Pastukhov Artem Olegovych
Pozdnyakova Natalia Heorgiivna
Stanovyy Oleksandr Petrovych
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2021-09-07
