Registration Number
0221U106907,
0119U101281
, R & D reports
Title
To study the clinical, metabolic, genetic and immune-inflammatory factors of the osteoporosis and sarcopenia progression among the patients with systemic lupus erythematosus and to identify the pharmacological correction approaches
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Head
Shevchuk Serhii V., Доктор медичних наук
Registration Date
22-12-2021
Organization
Vinnytsia National Pirogov Memorial Medical University
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The object of the study: patients with SLE, practically healthy people. The aim of the study: to improve the diagnosis of osteoporosis and sarcopenia in patients with SLE by the evaluation of bone mineral density indicators, mass, strength and/or functionality of skeletal muscle and metabolic features (osteocalcin, C-terminal propeptin of procollagen type I, pyrides, C-terminal telopeptide of collagen type I, N-terminal peptide of procollagen type III) their condition and connection with the course of the disease and other metabolic risk factors. The methods of the study: Comprehensive clinical and socio-medical examination, methods for assessing the activity and severity of SLE (SLEDAI and SLICC/ACRDI), enzyme-linked immunosorbent assay, vitamin D, thoracic and lumbar spine radiography, radiography of the hip joints, dual-energy X-ray absorptiometry), statistical methods. For the first time the prevalence and frequency of osteoporosis and sarcopenia and their relationships with traditional and metabolic risk factors and features of the underlying disease were studied in the Ukrainian population of SLE patients. It has been established that bone loss and sarcopenia are closely related to age increasing of patients, glucocorticoid load, index of internal organs damage, as well as disease activity. Low bone formation (C-terminal propeptide of procollagen type I, osteocalcin), and bone resorption (C-terminal telopeptide of collagen type I) markers were in 48.3% -51.3% patients with SLE as well as vitamin D deficiency was in 71.4 % patients with SLE and were associated with impaired structural and functional bone state, as well as with high GK doses, disease activity and severe functional disorders, and not related with age, disease duration and BMI. The levels of IL-6, osteocalcin, C-terminal telopeptide and serum estradiol have been found to be the main metabolic predictors that are most integrated into the pathogenesis of bone remodeling in women with SLE.
Product Description
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Bezsmertna Galyna V.
Bezsmertnyy Yuriy O.
Galyutina Olena Yur
Humeniuk O V
Denyshchych Liudmyla Petrivna
Dovgalyuk Tetyana Viktorivna
Kuvikova Inna Petrivna
Marynych Lyubov I
Segeda Iuliia S.
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2021-12-22
