Registration Number
0221U106946,
0119U001079
, R & D reports
Title
Prodnostic markers of the course of resistent arterial hypertension, developed on the basis of long-term observation data
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Head
Mishchenko Larysa A, Доктор медичних наук
Registration Date
23-12-2021
Organization
National Academy of Medical Sciences of Ukraine
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Predictors of unfavorable prognosis of patients with resistant arterial hypertension (RAG) have been identified. Increased chances of an unfavorable prognosis in patients with RAG are associated with higher baseline serum levels of citrulline (OR = 1.07; CI: 1.03 - 1.10), cystatin C (OR = 1.81; CI: 1.22 - 2.68), TNF-α (OR = 2.18; CI: 1.15 - 4.13), daily albuminuria (OR = 1.01; CI: 1.00 - 1.01), body mass index OR = 1.17; CI: 1.03 - 1.32) and lower baseline GFR-cC (OR = 0.96; CI: 0.93 - 0.99) and previous low adherence to antihypertensive therapy (OR = 2 , 63; CI: 1.11 - 6.21). The independent factors of growth of relative risk of occurrence of the combined end point include initial indicators of the maintenance of endothelial progenitor cells in blood ≤ 1818 cells / ml, level of average daily SAT> 163 mm of mercury. Art. and blood citrulline concentrations> 68 μmol / L. Based on the obtained data, a three-factor model created for predicting the risk of developing the primary endpoint - cardiovascular and renal complications as well as calculator for predicting the course of RAG.
Product Description
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Mishchenko Larysa A
Talaieva Tetiana V
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2021-12-23
