Registration Number
0221U106970,
0120U103984
, R & D reports
Title
Latent carbenes for organic synthesis
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Head
Kostyuk Oleksandr M.,
Registration Date
23-12-2021
Organization
Institute of Organic Chemistry NAS of Ukraine
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Reactions of silylformamidine with heterocyclic derivatives on the example of pyridines, pyrimidines, pyrazoles, thiophenes and their benzo analogues were studied. The influence of electron-accepting substituents in pyridines on the regioselectivity and the rate of the nucleophilic wedge reaction in the CH bonds of pyridines was determined. The possibility of synthetic use of this reaction to obtain the corresponding aldehydes was evaluated. The influence of temperature, the possibility of using catalysts, the method of control and analysis of the reaction are proposed. The reaction of silylformamidine with electron-enriched heterocycles on the example of thiophene was studied and the influence of electron-accepting substituents on the course of the reaction was determined. The most favorable conditions for the reaction, substituents that activate the reaction and the possible synthetic use of silylformamidine were determined.
Product Description
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Gurieva Anastasiia Mykolayivna
Kyrylchuk Andrii A.
Kostiuk Oleksandr M
Lysenko Viacheslav A.
Filimonchuk Serhii L
Shvydenko Tetiana Ivanivna
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2021-12-23
