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Information × Registration Number 0221U107049, 0121U110781 , R & D reports Title Annulated azine and azepine scaffolds for medical chemistry popup.stage_title Head Tkachuk Viktor M., Кандидат хімічних наук Registration Date 26-12-2021 Organization Institute of Organic Chemistry NAS of Ukraine popup.description2 N-Boc aminomethylfunctionalized 6-trifluoromethylpyrimidin-2(1H)-ones were obtained by organophotoredox catalyzed Giese-type reaction of N-Boc aminomethyltrifluoroborates with 4-CF3-pyrimidin-2(1H)-ones. Demonstrated that the cyclocondensation of (1,3-thiazolidin-2-ylidene)ketones with aroyl and thienoyl isothiocyanates is an effective approach to the construction of the new (2-methyl-5-aryl(heteryl)-7-thioxo-2,3--dihydro-7H-[1,3]thiazolo[3,2-c]pyrimidin-8-yl)ketones A novel PIFA-initiated oxidative cyclization of 2-(but-3-en-1-yl)quinazolin-4(3H)-ones into 1-(hydroxymethyl)-2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-ones. Showed that the halocyclization of N-allylbenzazepinamines is an effective method for the synthesis of new halomethyl-substituted imidazobenzazepines, promising molecular platforms for subsequent structural modification with biophoric groups. Elucidated the effect caused by the structure and electronic nature of the nucleophilic substrates and the electrophilic reagents on the regioselectivity of the cyclization which N-(1(2)-naphthyl) styrylacetamides undergo with arenesulfenyl chlorides. On this basis, a facile preparative route to arylthio substituted naphtho[1,2-b]- and naphtho[2,1-b]azepinones has been developed.The structure of all the synthesized compounds is definitely proved by spectral methods and X-ray diffraction analysis. A convenient approach to obtaining new biopromising derivatives has been developed 8-(alkylimino)-4,8-dihydro-1Н-[1,2,3]triazolo[4,5-e][1,4]thiazepin-5(6Н)-ones and 5-oxo-4,5-dihydro-1Н-[1,2,3]triazolo[4,5-b]pyridine-6-carboxylic acids. Product Description popup.authors Danyliuk Ivanna Yu. Kemskii Sergiy V Litvinchuk Mariia B Savinchuk Natalia O Tkachuk Viktor M. popup.nrat_date 2022-03-09 Close