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Information × Registration Number 0222U000502, 0119U103007 , R & D reports Title Determine the role of cyclooxygenase-2 inhibitors in combination with cytostatics in radiomodification of radiation therapy for non-small cell lung and squamous cell carcinoma of the head and neck popup.stage_title Head Mitryaeva Nataliya A., Доктор біологічних наукStarenkiy Viktor P., Доктор медичних наук Registration Date 11-01-2022 Organization State Organization "Grigoriev Institute for Medical Radiologiy of the National Academy of Medical Sciences of Ukraine" popup.description2 The object of study: the effectiveness of radiation therapy in combination with cisplatin in patients with non-small cell lung cancer (NSCLC) and squamous cell carcinoma of the head and neck (PRGS) with the content of PEG-2, COX-2 and VEGF 2 in blood serum. The aim of the work: is to increase the effectiveness of radiation therapy of non-small cell lung cancer and squamous cell carcinoma of the head and neck by radiomodification with cyclooxygenase-2 inhibitors (celecoxibs) in combination with cytostatics (cisplatin) based on determining the mechanisms of their radiosensitizing action. Methods of research and equipment: clinical and instrumental, immunoassay, statistical; the immunoenzymometric analyzer Immunochem-2100, the linear accelerator Clinac-600. Theoretical and practical results: found that the use of RT in combination with cisplatin in patients with NSCLC regression rate reaches 83.3%, with radiation therapy with COX-2 inhibitor and cisplatin - 88.9%, positive response in patients with PRGS was in 75% of cases. Local radiation reactions and hematological toxicity do not exceed I-II degree. Radiation dermatitis and radioepitheliitis did not exceed grade III, hematological toxicity - grade II. It is proved that RT with the use of radiomodification in patients decreases in the level - VEGF, PGE-2 and COX-2 are more pronounced with combined action of radiation, cisplatin and ranselex, indicating increased antiangiogenic effect. Novelty: scientific data were obtained on the effect of various radiation therapy regimens in combination with COX-2 inhibitors, cisplatin and cisplatin and ranselex on the content of VEGF and COX-2 and PGE-2 in serum. Supplemented data on the effectiveness of RT in combination with cisplatin on the direct results of treatment in patients with NSCLC and PRGS. Effectiveness of implementation: increasing the duration of the relapse-free period and improving the quality of life of patients. Domain of usage: radiation oncology. Product Description popup.authors Artiukh Serhii Volodymyrovych Bilozor Nataliia Volodymyrivna Bilchenko Iryna Viktorivna Grebinyk Lidiya Volodymyrivna Kolomatska Viktoriia Volodymyrivna Kondrashova Olena Ivanivna Makaruk Olena Viktorivna Potapova Tetiana Ivanivna Pshyshevska Liudmyla Anatoliivna Tkachenko Alla Anatoliivna popup.nrat_date 2022-03-09 Close