Registration Number
0222U000502,
0119U103007
, R & D reports
Title
Determine the role of cyclooxygenase-2 inhibitors in combination with cytostatics in radiomodification of radiation therapy for non-small cell lung and squamous cell carcinoma of the head and neck
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Head
Mitryaeva Nataliya A., Доктор біологічних наук
Starenkiy Viktor P., Доктор медичних наук
Registration Date
11-01-2022
Organization
State Organization "Grigoriev Institute for Medical Radiologiy of the National Academy of Medical Sciences of Ukraine"
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The object of study: the effectiveness of radiation therapy in combination with cisplatin in patients with non-small cell lung cancer (NSCLC) and squamous cell carcinoma of the head and neck (PRGS) with the content of PEG-2, COX-2 and VEGF 2 in blood serum. The aim of the work: is to increase the effectiveness of radiation therapy of non-small cell lung cancer and squamous cell carcinoma of the head and neck by radiomodification with cyclooxygenase-2 inhibitors (celecoxibs) in combination with cytostatics (cisplatin) based on determining the mechanisms of their radiosensitizing action. Methods of research and equipment: clinical and instrumental, immunoassay, statistical; the immunoenzymometric analyzer Immunochem-2100, the linear accelerator Clinac-600. Theoretical and practical results: found that the use of RT in combination with cisplatin in patients with NSCLC regression rate reaches 83.3%, with radiation therapy with COX-2 inhibitor and cisplatin - 88.9%, positive response in patients with PRGS was in 75% of cases. Local radiation reactions and hematological toxicity do not exceed I-II degree. Radiation dermatitis and radioepitheliitis did not exceed grade III, hematological toxicity - grade II. It is proved that RT with the use of radiomodification in patients decreases in the level - VEGF, PGE-2 and COX-2 are more pronounced with combined action of radiation, cisplatin and ranselex, indicating increased antiangiogenic effect. Novelty: scientific data were obtained on the effect of various radiation therapy regimens in combination with COX-2 inhibitors, cisplatin and cisplatin and ranselex on the content of VEGF and COX-2 and PGE-2 in serum. Supplemented data on the effectiveness of RT in combination with cisplatin on the direct results of treatment in patients with NSCLC and PRGS. Effectiveness of implementation: increasing the duration of the relapse-free period and improving the quality of life of patients. Domain of usage: radiation oncology.
Product Description
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Artiukh Serhii Volodymyrovych
Bilozor Nataliia Volodymyrivna
Bilchenko Iryna Viktorivna
Grebinyk Lidiya Volodymyrivna
Kolomatska Viktoriia Volodymyrivna
Kondrashova Olena Ivanivna
Makaruk Olena Viktorivna
Potapova Tetiana Ivanivna
Pshyshevska Liudmyla Anatoliivna
Tkachenko Alla Anatoliivna
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2022-03-09
