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Information × Registration Number 0222U000683, 0117U004134 , R & D reports Title Synthesis, structure, properties and molecular mechanisms of action of new antithrombotic and antiviral agents. popup.stage_title Head Andronati Serhii A., д.х.н. Registration Date 14-01-2022 Organization Physico-Chemical Institute O. Bogatsky National Academy of Sciences of Ukraine popup.description2 The work is devoted to the synthesis and study of the biological activity of new antagonists to the "closed form" of fibrinogen receptors, potential antiviral agents, interferon inducers, DNA ligands and anti-inflammatory agents. study of the influence of structure on biological properties. Directed synthesis of 2- (homopiperazin-1-yl) quinazolin-4-one derivatives was performed. Derivatives of 2,6-substituted quinazolin-4-one have been shown to inhibit fibrinogen binding to αIIbβ3 and their antiplatelet properties have been studied. The main centers of binding of 2- (piperazin-1-yl) quinazoline derivatives to αIIbβ3 were established by the method of molecular docking. Synthesized 9-R-6-H-indolo [3,2-b] quinoxalines, based on substituted isatins and water-soluble analogues. By condensation of 6-unsubstituted and 6-bromonaphthalic anhydride with ammonia, hydrazine hydrate and hydroxylamine, the corresponding naphthalimide derivatives were synthesized. Condensation of ninhydrin with substituted 1,2-diaminobenzenes synthesized new derivatives of indenoquinoxaline, from the latter - the corresponding oximes. Condensation of isatin with isate anhydride yields tritantrins and corresponding oximes. Indenoquinoxalinones have been shown to be DNA intercalators. Indenoquinoxalines, indolo [2,1-b] quinazoline-6,12-diones and their oximes have been studied for their ability to inhibit the induced production of pro-inflammatory cytokines and to inhibit the development of carrageenan-induced edema. Active in vitro at micromolar concentrations and active in vivo at a dose of 34 μmol/kg of compound were detected. The GTM procedure was used to form and study the chemical space of various antiviral agents. As a result, two-dimensional maps have been constructed, on which compact zones of chemical space associated with various antiviral agents against viruses of different taxonomic groups (Enterovirus, Hepacivirus, Orthomyxoviridae, Lentivirus, Orthohepadnavirus, Pestivirus, Herpesvir  Product Description popup.authors Illyushko Natalia О. Andronati Serhii A. Karpenko Oleksandr S. Kornylov Oleksandr Yu. Krysko Andrii А. Krysko Olga L. Kuzmin Viktor Ye. Mikhaylova Tetiana V. Shibinska Marina O. popup.nrat_date 2022-03-09 Close