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Information × Registration Number 0222U001048, 0119U001084 , R & D reports Title To study the peculiarities of lesion of the cardiovascular system and formation of coronary atherosclerosis in patients with diabetes mellitus popup.stage_title Head Sokolova Liubov K, Registration Date 23-01-2022 Organization State Institute "V.P. Komissarenko Institute Of Endocrinology And Metabolism of The National Academy of Medical Science of Ukraine" popup.description2  The object of the study - patients with diabetes mellitus type 1 and 2 with damage to the cardiovascular system. The aim of the study was to study the features of pathophysiological and pathomorphological mechanisms of cardiovascular damage and the formation of coronary atherosclerosis in patients with diabetes. Research methods - general clinical, instrumental, laboratory, enzyme-linked immunosorbent assay, statistical. Equipment - enzyme-linked immunosorbent assay Stat Fax 3200. The results obtained: Based on the assessment of the database of the Department of Surgical Treatment of Ischemic Heart Disease of the National Institute of Cardiovascular Surgery. M.M. Amosova NAMS of Ukraine "for the period 2017-2020, we can say that the incidence of diabetes in patients with cardiovascular disease is 9.2%, ie every tenth patient with cardiac pathology has a violation of carbohydrate metabolism. In the study of the activity of adenosine monophosphate-activated protein kinase (AMPK) for the first time it was shown that metformin increases the activity of AMPK in the lymphocytes of patients with type 2 diabetes. Increased activity of AMPK in blood cells indicates a possible universal effect of metformin and dapagliflozin on all body tissues. Elevated plasma levels of high-density lipoprotein (HDL) and apolipoprotein A1 (ApoA1) are associated with a reduced risk of cardiovascular disease (CVD). Product Description popup.authors Belchina Uliia Boguslavivna Zubkova Galyna Anatoliivna Luchyckiy Yevgen Vasyliovych Luchitskiy Vitaliy Yevgenovych Rybalchenko Viktoriya Mykolayivna Sokolova Liubov Kostyantynivna Tkach Sergiy Mykolayovych Tsymbal Tetiana Serhiivna Cherviakova Svitlana Anatoliyovna popup.nrat_date 2022-03-09 Close