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Registration Number

0222U001099, 0120U101650 , R & D reports

Title

Development of techniques for analysis and study of 1,2,4-triazole derivatives as promising active pharmaceutical ingredients using high performance liquid chromatography

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Head

Kaplaushenko Andrii H., Доктор фармацевтичних наук

Registration Date

24-01-2022

Organization

Zaporizhzhya State Medical University

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 Object of research: morpholine 2-((4-(2-methoxyphenyl) 5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl) thio)acetate(“Thiometrizol”), sodium 2 ((4-amino-5-thiophen-2-ylmethyl) -4H-1,2,4-triazol-3-yl)thio) acetate (ASP-34), 2-(thiophen-2-yl)acetohydrazide, potassium 2-(2-(thiophen-2-yl)acetyl)hydrazine-1-carbodithionate, 4-amino-5-(thiophen-2-ylmethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione and other derivatives of 1,2,4-triazole. The purpose of the study: Creating scientific approaches to the chromatography with mass spectrometry methods for establishing purity, molecular mass, structure, identification and quantification of a number of derivatives 1,2,4-triazole, development and validation of methods that allow control the content of these substances in intermediates, active pharmaceutical ingredients, drugs and biological liquids. Research methods: High performance liquid chromatography with diode-matrix detection, mass spectrometry, thermodynamic method, pharmacokinetic method. Results and their novelty. The main trends in creating new methods of analysis of 1,2,4-triazole derivatives are to increase the use of HPLC and HPLC-MS methods. However, for the studied derivatives 3-thio-1,2,4-triazoles lag behind the world trends, namely for these substances are usually offered mostly spectrophotometric or potentiometric methods that are insensitive, non-selective.

Product Description

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Bukhtiiarova Nina V
Varynskyi Borys O.
Vasiuk Svitlana O.
Rudakova Olga O.
Frolova Yuliia S.

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2022-03-09