Registration Number
0222U001725,
0119U002525
, R & D reports
Title
Development of novel ultrasound and fluorescence methods for medical macro- and microdiagnostics.
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Head
Gorbenko Galyna P., Доктор фізико-математичних наук
Registration Date
02-02-2022
Organization
V.N. Karazin Kharkiv National University
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New peculiarities of the formation of ultrasound Doppler response at acoustic remote palpation of the soft tissues in the process of the thermal ablation using high-intensive focusing ultrasound were revealed. The ultrasonic Doppler method of studying the elastic properties of the soft tissues using the method of shear wave elastography has been proposed. The general theory suitable for the description of the spectral characteristics of ultrasonic Doppler signals applying the modern technology of the dynamic focusing of the emitted ultrasonic beams by the method of general synthetic aperture was developed. A computer simulation of the formation and chemical annealing behavior of non-bridging oxygen hole centers in silica exposed to long-time hydrogen implantation have been performed. New cyanine and phosphonium dyes were tested for their ability to serve as markers of pathogenic protein aggregates, amyloid fibrils. The method of detecting the amyloid aggregates through measuring the Förster resonance energy transfer in the system of two classical amyloid markers, Thioflavin T and Congo red, has been suggested. The impact of monomeric and fibrillar lysozyme on the structural state and physicochemical properties of the model lipid membranes was investigated using the fluorescence spectroscopy technique and computer modelling. The ability of 23 novel cyanine dyes to serve as potential inhibitors of the formation of insulin amyloid fibrils under physiological conditions in vitro was evaluated. The results obtained allow the optimization of the various Doppler techniques by the general synthetic aperture method, as well as to develop new approaches to the theranostics of amyloid diseases.
Product Description
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Barannik Evgen O.
Vus Kateryna O.
Gorbenko Galina P.
Zhitnyakivska Olga Anatoliivna
Tarabara Uliana Kostiantynivna
Trusova Valeriya Mykhaylivna
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2022-03-09
