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Registration Number

0222U001856, 0119U100168 , R & D reports

Title

Biochemical aspects of the functioning of metabolic and signaling pathways under the influence of protein molecules in the conditions of normal and pathologically altered metabolism.

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Head

Savchuk Oleksii M., Доктор біологічних наук

Registration Date

03-02-2022

Organization

Taras Shevchenko National University of Kyiv

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Object of research: biochemical processes and metabolic cycles under the action of newly formed / modified in the conditions of development of pathological conditions molecules of protein nature. Objective: to determine the potential effects of effectors of protein nature (autoantibodies, peptides, abnormal forms of proteins and partially degraded forms of enzymes) formed in the body with the development of pathological conditions of various etiologies and molecules used as potential pharmacological agents of new generation (newly synthesized chemicals compounds, nanostructured materials, biological molecules) for key biochemical processes and signaling cascades under conditions of normal and pathologically altered metabolism. Research methods: biochemical (spectrophotometric, chromatographic, electrophoretic), enzyme-linked immunosorbent assay, molecular, histological and methods of mathematical statistics. For the first time, a comprehensive study of the state of the hemostasis system in patients with ischemic stroke was conducted, which allowed to supplement the existing ideas about the biochemical basis of development and progression of this pathology. The prothrombogenic nature of changes in the hemostasis system due to asynchrony in the functioning of all components of this system has been confirmed. A comparative analysis of the parameters characterizing the state of the fibrinolysis system, the results of which revealed a decrease in fibrinolytic potential in patients with ischemic stroke. It was found that the acute period of ischemic stroke is characterized by the development of endogenous intoxication, confirmed by the accumulation in the serum of medium weight molecules, oligopeptides and a decrease in the concentration of total protein and albumin.

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Batsmanova Ludmyla M.
Vereshchaka Volodymyr V.
Halyenova Tetyana І.
Dvorshchenko Kateryna O.
Dunich Alina A.
Koval Tetyana V.
Kosyan Anatolij M.
Kot Larysa I.
Olefirenko Viktoriya V.
Ostapchenko Liudmyla I.
Raksha Nataliya G.
Svechnikova Oksana S.
Snigur Halyna O.
Huet Alevtina S.

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2022-03-09