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Information × Registration Number 0222U001957, 0117U000786 , R & D reports Title Enhancement the efficiency of conventional and experimental drugs in vitro and in vivo through their immobilization on nanoscale carriers and such carriers combined with antioxidants popup.stage_title Head Стойка Ростислав Степанович, Registration Date 04-02-2022 Organization Institute of Cell Biology popup.description2  The obtained results demonstrated that immobilization of water-insoluble biologically active substances (landomycins or heterocyclic substances derived from 4-thiazolines) on amphiphilic polymer nanocarriers (poly-2-oxazoline or PEG-containing comb-like polymers) resulted in the formation of water-soluble substances that are convenient for application, especially for administration to animals. The application of the above-mentioned polymers and C60 fullerene as carriers for the delivery of antitumor agents allowed to enhance their toxicity and to overcome the multiple drug resistance of target tumor cells. Immobilization of landomycin A on poly-2-oxazoline polymer to significantly increased the storage stability of this antibiotic. It has been found that ferromagnetic nanoparticles with a solid lipid coating, even without conjugated antitumor factors, effectively reduced the growth of target tumor cells. All above mentioned nanocomposites of antitumor factors, including newly synthesized thiazole derivatives and 4-thiazolidinones, induce apoptosis in target tumor cells. It is important to note that the immobilization of traditional (doxorubicin or cisplatin) or experimental (thiazole and 4-thiazolidinone derivatives) antitumor factors significantly reduces their negative side effects that these factors caused in animals with tumors undergoing chemotherapy. We have estimated for the first time the mechanisms of the action of antibiotic landomycin A and new derivatives of thiazole and 4-thiazolidinone on target tumor cells. These allow us to move to the next stage of preclinical studies of these experimental agents. We have developed derivatives of natural polymer chitosan with reduced molecular weight, lower viscosity and improved water solubility, which are much better than native chitosan carriers of antitumor factors and antimicrobial drugs. Product Description popup.authors Ivasechko Iryna Ihorivna Antoniuk Volodymyr Oleksandrovych Кit Yuriy Yaroslavovych Kashchak Nataliya I. Klishch Mykola Vasylovych Klyuchivska Olga Yu. Kozak Yuliia S. Lootsik Maxim D. Manko Nazar Olegovych Panchuk Rostyslav R. Senkiv Yuliya V. Skorokhyd Nadiya R. Starykovych Marina O. Stoika Rostyslav Finiuk Nataliya S. popup.nrat_date 2022-03-09 Close