Registration Number
0222U002481,
0119U000617
, R & D reports
Title
Pharmacological study of cardio- and gastroprotective properties of biotechnological, plant origin and synthetic drugs
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Head
Oleshchuk Oleksandra Mykhailivna, Доктор медичних наук
Registration Date
13-02-2022
Organization
Ternopil National Medical University named after I. Gorbachevsky of the Ministry of Health of Ukraine
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GDR report: 88 pages, 82 sources, 8 figures, 22 tables.
Cardical autonomous neuropathy, metformin, diabetes mellitus, hepatitis, chamery narrow-leaved, l-ornithine-l-aspartate, dry extract from mushrooms raveshe, a thick extract from fungi shiitake, a thick extract of mateware, doxorubicin cardiomyopathy, carbon enterosorbent, granulocytic colony stimulating factor, CYTOSTATIC MYELODEPRESSION, MELPHALANE, ENTEROSORPTION.
Object of research - cardioprotective effects of metformin in conditions of hypoxia and metabolic stress and isoproterenol-induced myocardial damage; pharmacological properties of extracts of hemia herb narrow-leaved, as well as dry extract of Reishi mushrooms and thick extracts of Shiitake and Maitake mushrooms in acute carbon tetrachloride toxic liver disease; toxic effects of doxorubicin and their correction with the help of the original granular carbon enterosorbent and granulocyte colony-stimulating factor (G-CSF) preparations.
The aim of the study was to study the cardioprotective effects of metformin in vitro under conditions of hypoxia and metabolic stress and in isoproterenol-induced myocardial damage; to study the pharmacological properties of lyophilized extract of the herb Chameria narrowleaf (LETH), its acute toxicity, local irritant and ulcerogenic action; to establish a conditional therapeutic dose of dry extract of Reishi mushrooms (SEGR), thick extracts of Maitake mushrooms (GEGM) and Shiitake mushrooms (GEGSH) in an experiment on rats with simulated tetrachloromethane hepatitis; to study the acute toxicity of GESH, GEGM and SEGR; to study the effectiveness of carbon enterosorbent when used alone and in combination with granulocyte colony-stimulating factor drugs to reduce the side effects of doxorubicin, to determine the effects of enteral sorption therapy and granulocyte colony stimulant antihypertensive agent on the indicators;
Product Description
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2022-03-09
