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Registration Number

0222U003320, 0121U112008 , R & D reports

Title

Study of biological properties of new pyrazole-containing bisphosphonates as potential regulators of bone metabolism

Head

Labudzynskyi Dmytro O., Кандидат біологічних наук

Registration Date

06-03-2022

Organization

Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine

Description

 Loss of bone mass is the main cause of most skeletal diseases. Drugs that can inhibit bone loss by inhibiting bone resorption are calcium, estrogen, calcitonin, bisphosphonates and vitamin D3. However, the drugs of the first link of protection against bone loss are bisphosphonates. Bisphosphonates remain one of the most effective means of treating diseases of the musculoskeletal system, and the development of new and more advanced analogues has broad prospects for practical application. Combining the methods of bioinformatics analysis and virtual screening among a wide range of possible options, a number of bisphosphonate analogues were selected and synthesized, the pyrazole derivatives of which were chosen as radicals. In order to further study the biological, in particular antiresorptive, properties of pyrazole-containing bisphosphonates, their effect on the metabolic activity of J774A.1 cells and primary rat hepatocyte culture was studied by the MTT method, as well as their general antioxidant, antioxidant and DP-binding activity.

Product Description

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Paliienko Konstantin O.