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Information × Registration Number 0222U003506, 0121U109941 , R & D reports Title Photocontrolled analogues of natural cytotoxic peptides for immunotherapy of metastatic cancer popup.stage_title Head Komarov Ihor V., Доктор хімічних наук Registration Date 05-04-2022 Organization Taras Shevchenko National University of Kyiv popup.description2 Object of study: Peptides with photocontrolled cytotoxic properties. Purpose: design, synthesis, study of peptides, which at photoactivations in tumors cause immunogenic cell death and as a result - a powerful response of the immune system, which can be used in innovative approaches to cancer immunotherapy. Research methods: organic synthesis, computer modeling, analysis using physical methods. The natural cytotoxic peptide Jimnopeptide B, as well as its photocontrolled analogues with different positions of the diarylethene photosensitive fragment in molecules, have been comprehensively studied by molecular dynamics methods. According to the results of calculations, the following analogues have been found significantly different molecule structures depending on the photoisomeric form of the diarylethen moiety. From among these analogues selected for further synthesis is one that has one of the photoisomeric forms most similar in structure and dynamics to the prototype, Jimnopeptide B. Synthesized Jimnopeptide B and completed the synthesis of key intermediates on the way to obtaining the selected results calculations of photosensitive analogue. A study of the toxicity and effectiveness of antitumor activity, signs of activation of the immune system using a model compound LMB040 - an analogue of Jimnopeptide B in a chemically induced model of hepatocellular carcinoma of rats. Also on the model connection LMB040 methods of photoconversion analysis were developed photosensitive peptides using high performance liquid chromatography.  Product Description popup.authors Veselskiy Stanislav P. Garmanhuk Ludmila V. Danko Volodymyr P. Kovalenko Andriy V. Kravchenko Andrii A. Radchenko Dmytro S. Stupak Yuliya A. Tsuvariev Oleksandr Yu. Shtanova Lidiya Ya. Yanchuk Petro І. popup.nrat_date 2022-04-05 Close