Registration Number
0222U003646,
0121U110087
, R & D reports
Title
Individualization of combined treatment of colorectal cancer of III-IV stages of the disease based on the study of molecular markers of redox status of tumor progression
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Head
Lukashenko Andrii V., Доктор медичних наук
Registration Date
11-05-2022
Organization
National Cancer Institute
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Object of study: patients with colorectal cancer. Objective: to improve the oncological and direct results of treatment of patients with stage IV colorectal cancer by studying the prognosis of treatment response based on molecular markers of redox status of tumor progression. Parenchymal conservation surgery in patients with colorectal cancer with liver metastases affecting the central sites of the liver is an effective and oncologically safe method. Severe postoperative complications in the groups of central liver sites and peripherally localized metastases were 24.4% and 21.8%, respectively (p = 0.15), and overall 3-year survival was (53 ± 9)% and (59 ± 15). )%, (p = 0.3). It was found that the formation of metastatic microenvironment in the liver is provided by the generation of superoxide radicals and NO-activation of gelatinases MMP-2, which remodel the intercellular matrix in the parenchyma of the operated liver. The rate of generation of superoxide radicals in the adjacent to metastasis and distant liver parenchyma was (1.09 ± 0.19) nmol / g of raw tissue ∙ min and (0.36 ± 0.03) nmol / g of raw tissue ∙ min, p <0.01). The activity of MMP-2 in the adjacent to metastasis and distant relatively healthy parenchyma of the operated liver was respectively (6.88 ± 1.31) in. at. and (3.73 ± 0.60) y. o., (p <0.01). The study showed that the use of preconditioning with sevoflurane in patients during liver resection did not significantly affect the functional capacity of the liver. Further research is needed to include more patients.
Product Description
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Sikachev Sergey S.
Burlaka Anton A.
Ganul Andrey V.
Zakalska Khrystyna А.
Zubarev Nikolay G.
Kvasivka Oleksandr O.
Kopchak Kostantin V.
Lisnyy Ivan І.
Minich Alina V.
Makhmudov Dmytro E.
Nazarov aroslav S.
Yatsyna Oleksandr І.
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2022-05-11
