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Registration Number

0222U004576, 0120U101957 , R & D reports

Title

Synthesis of rhenium compounds with antioxidant and luminescent properties and research of their specific interaction with biological molecules.

Head

Shtemenko Oleksandr V., Доктор хімічних наук

Registration Date

12-09-2022

Organization

Ukrainian State University of Chemical Technology

Description

 The object of study - physico-chemical and biological properties compounds of Re(III) and Re(I). The aim of the work is the obtain a complex of next experimental data: the interaction of rhenium(III) cluster compounds with dicarboxylic aminoacids, derivatives of azoles, dipeptides and the definition of their physicochemical properties; with natural unsaturated hydroxycarboxylic acids of the cinnamic classes and the confirmation of their structure by physicochemical methods, and the synthesis and structure of Re(I) complexes with heterocyclic ligands. Research methods -physicochemical methods, electrical conductivity, electronic, nuclear magnetic resonance (NMR) and infrared (IR) -spectroscopy. The interaction of rhenium(III) cluster compounds investigated: with dicarboxylic amino acids (aspartic and glutamic acids) and some derivatives of azoles (imidazole, benzimidazole); with dipeptides (glycyl-glycine, glycyl-phenylalanine) and their physicochemical properties was determined; with natural unsaturated hydroxycarboxylic acids of the cinnamic classes; the structure of target Re(I) complexes was considered. Synthesized cluster rhenium(III) compounds: with dicarboxylic aminoacids; with azoles; with dipeptides; with unsaturated hydroxycarboxylic acids. The target Re(I) complexes were obtained. Produced: the receiving method of rhenium(III) complex compounds with dipeptides and a new technical solution, an application for obtaining a protection document for the object of intellectual property rights was submitted. Field of use: C 20.59 Manufacture of other chemical products; C 21.20 Manufacture of pharmaceutical preparations and materials; P 85.42 Higher education; Q 86.90 Other health care activities.

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Bilenka Zhanna V.
Berzenina Oksana V.
Velychko Olena V.
Holichenko Oleksandr А.
Husak Yuliia V.
Zeleniuk Kateryna V.
Kytova Dina Y.
Malook Maksym V.
Ovcharenko Alina O.
Panteleieva Olha S.
Polokhina Kateryna V.
Slipkan Anastasiia V.
Shtemenko Nataliia I.
Shtemenko Oleksandr V.