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Information × Registration Number 0222U005239, 0117U003840 , R & D reports Title Investigation and synthesis of organic compounds modified by fluoro-containing substituents using novel commercial fluoroalkanes and fluoroalkenes. popup.stage_title Head Yagupolskii Yurii L., Доктор хімічних наук Registration Date 26-12-2022 Organization Institute of Organic Chemistry NAS of Ukraine popup.description2 A systematic study of the synthetic potential of commercially available industrial fluoroalkenes and fluoroalkynes was carried out and it was shown that they are convenient synthons for introducing fluorine-containing fragments into organic molecules; the catalytic hydrosilylation of commercial fluorine-containing propenes and butenes with the participation of chlorosilanes was investigated and a series of new fluorine-containing silanes containing one or two trifluoromethyl groups was obtained; the reactivity and the possibility of functionalization of the new 1,1,4,4,4-pentafluorobut-1-ene were studied; it is shown that E-1-chloro-3,3,3-trifluoropropene interacts with alcohols and phenols to form the corresponding vinyl ethers with satisfactory yields, and the products of interaction with polyols are of interest as potential foaming agents; found the conditions under which bis(trifluoromethyl)acetylene undergoes a Diels-Alder reaction with naphthalene derivatives to form benzobarelene derivatives; the conditions of catalytic hydrosilylation of hexafluorobutene with hydrosilanes in mild conditions were developed and a number of new vinyl silanes with high yields were obtained; a convenient and simple method for obtaining aliphatic, aromatic and heterocyclic trifluoromethyl sulfides with high yields was developed; a convenient method of oxidizing the obtained trifluoromethyl sulfides to the corresponding trifluoromethyl sulfoxides without over-oxidation to sulfones was found; the cyclopropanation reaction of trifluoromethylsulfinyl and trifluoromethylsulfonyl ethylenes was studied; convenient preparative methods for the synthesis of 2-chloro-5-trifluoromethoxypyrazine were found and it was demonstrated that the molecule is a convenient synthon for further transformations by replacing the chlorine atom with an amino group, alkyl substituents, aromatic and unsaturated groups, as well as an ethynyl substituent. Product Description popup.authors Babadzhanova Lesia A Boiko Volodymir M Kirij Nataliia Kremlev Michail M Mushta Aleksej Ivanovich Orlova Raisa K Pavlenko Nataliia V Петко Кирил Ігорович Pysarenko Mariia M. Sokolenko Liubov V. Sokolenko Taras M. Filatov Andrey A popup.nrat_date 2022-12-26 Close